• Butterfield, Rita M.
  • Evans, James P.
  • Rini, Christine
  • Kuczynski, Kristine J.
  • Waltz, Margaret
  • Cadigan, R. Jean
  • Goddard, Katrina A. B.
  • Muessig, Kristin R.
  • Henderson, Gail E.
2018
Genetics in Medicine
Full article

In genomics, the return of negative screening results for rare, medically actionable conditions in large unselected populations with low prior risk of disease is novel and may involve important and nuanced concerns for communicating their meaning. Recruitment may result in self-selection because of participants’ personal or family history, changing the characteristics of the screened population and interpretation of both positive and negative findings; prior motivations may also affect responses to results.