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In the United States, about 6.5 million adults are living with heart failure, and about half of those patients will die within 5 years of diagnosis.1 For patients with advanced chronic heart failure or acute unrecoverable decompensation, heart transplantation offers a cure. However, the number of patients with end-stage heart failure is increasing while the availability of donor hearts is decreasing,2 leaving clinicians to consider options such as mechanical circulatory support (MCS).