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Attitudes About Analytic Treatment Interruption (ATI) in HIV Remission Trials with Different Antiretroviral Therapy (ART) Resumption Criteria

January 8, 2022

HIV remission trials often require temporary stopping of antiretroviral therapy (ART)—an approach called analytic treatment interruption (ATI). Trial designs resulting in viremia raise risks for participants and sexual partners. We conducted a survey on attitudes about remission trials, comparing ART resumption criteria (lower-risk “time to rebound” and higher-risk “sustained viremia”) among participants from an acute … Continued

Ethical Considerations for HIV Remission Clinical Research Involving Participants Diagnosed During Acute HIV Infection

December 28, 2021

HIV remission clinical researchers are increasingly seeking study participants who are diagnosed and treated during acute HIV infection—the brief period between infection and the point when the body creates detectable HIV antibodies. This earliest stage of infection is often marked by flu-like illness and may be an especially tumultuous period of confusion, guilt, anger, and … Continued

A Review of Public Health, Social and Ethical Implications of Voluntary Medical Male Circumcision Programs for HIV Prevention in Sub-Saharan Africa

October 26, 2021

Ideally, the benefits of public health interventions should outweigh any associated harms, burdens, and adverse unintended consequences. The intended benefit of voluntary medical male circumcision (VMMC) programs in eastern and southern Africa (ESA) is the reduction of HIV infections. We review the literature for evidence of reductions in HIV incidence, evaluate the extent to which … Continued

New Collaboration between UNC and Stellenbosch University, South Africa

September 16, 2021

The Research for Ethical Data Science in Southern Africa (REDSSA) project has the overall aims of producing new knowledge regarding the ethical, legal and social implications (ELSI) of conducting data science research to develop evidence-based, context specific guidance for the conduct and governance of data science initiatives such as DS-I Africa, and to strengthen the … Continued

The Ethics of Stigma in Medical Male Circumcision Initiatives Involving Adolescents in Sub-Saharan Africa

April 15, 2021

Ongoing global efforts to circumcise adolescent and adult males to reduce their risk of acquiring HIV constitute the largest public health prevention initiative, using surgical means, in human history. Voluntary medical male circumcision (VMMC) programs in Africa have significantly altered social norms related to male circumcision among previously non-circumcising groups and groups that have practiced … Continued