The center interprets “bioethics” as a broad domain of questions about ethical issues in the life sciences and health care, rather than a research discipline.
Jill A. Fisher is a co-author on a new letter in The Lancet: “Declaration of Helsinki’s missed opportunity for healthy volunteer trials.” The authors “applaud the Declaration of Helsinki,” but suggest that it “does not go far enough” when mentioning healthy research volunteers. The authors also reference the first Global Ethics Charter for the Protection … Read more
R. Jean Cadigan is a co-author on a new article in Journal of Empirical Research on Human Research Ethics. In “Ready, Set, Sort! A User-Guide to Card Sorts for Community-Engaged Empirical Bioethics,” the authors demonstrate the “fruitfulness of using card sort activities as an engagement method” and include a user guide.
Mara Buchbinder is the first author on a new commentary article in Chest: “Organizational Resilience: A Systems-Based Approach for Addressing the Workforce Crisis in Intensive Care.” The researchers propose a novel, systems-based approach to addressing burnout, with a focus on works in intensive care environments. The commentary suggests organizational resilience as a promising new approach … Read more
Rebecca L. Walker is the author of chapter 41, “Physicians and Punishment: Ethics beyond oaths and codes” in The Oxford Handbook of the Philosophy of Punishment, ed. Jesper Ryberg. Abstract: Despite orientation to goals that are in deep tension, medicine and state-sanctioned punishment have long cooperated. Involvement of physicians in some punishment practices has led … Read more
Stuart Rennie is the first author on a new article in Public Health Ethics: “Ethics of Mathematical Modeling in Public Health: The Case of Medical Male Circumcision for HIV Prevention in Africa.” The authors call for greater research and reflection on the ethics of mathematical modeling public health. They use a case study to highlight … Read more
Stuart Rennie is a co-author on a new article in Research Ethics: “Exploring views of South African research ethics committees on pandemic preparedness and response during COVID-19.” The authors did in-depth interviews to explore the views of South African research ethics committees (RECs) on their COVID-19 pandemic preparedness and response. The authors highlight important preparedness … Read more
by Brittany Phillips, UNC Health Publishing in Annals of Allergy, Asthma and Immunology, UNC School of Medicine researchers delve into the perspectives of community and academic providers on the role of biologics and food allergy. This study was led by co-authors Edwin Kim, MD, Division Chief of Pediatric Allergy and Immunology, and Jill Fisher, PhD, … Read more
Jill A. Fisher and Maral Erol are co-authors, with colleague Edwin H. Kim, on a new article in Annals of Allergy, Asthma & Immunology. The researchers interviewed providers in community practice or academic medical centers. They asked providers about “their perceptions of the risks and benefits of current and future FA treatment options,” with a … Read more
Since the June 2022 U.S. Supreme Court ruling in Dobbs v. Jackson Women’s Health Organization, 18 states have put functional abortion bans in place. New research fills a gap in understanding impacts on physicians after these bans. Mara Buchbinder, Kavita S. Arora and colleagues identify sources of moral distress impacting physicians. Moral distress occurs when … Read more
Margaret Waltz and Jonathan S. Berg are co-authors, with colleagues, on a new article in Genetics in Medicine. The researchers “investigated associations between GBMM [group-based medical mistrust]” and perceptions of a specialty care appointment. The study includes perspectives from caregivers of child patients and from providers. Findings “extend evidence for detrimental effects of GBMM on … Read more
The PREPARE (PRomoting Equity for Pregnant Adolescents in REsearch) research team participated in AIDS 2024, the 25th Annual AIDS Conference sponsored by the International AIDS Society in Munich, Germany. A day prior to the conference the PREPARE team convened the first meeting of the PREPARE Working Group for a half-day workshop. Members of the PREPARE working group … Read more
Bioethics Forum Essay “Was This Job Market Study Ethical?”, Douglas MacKay, PhD, and Katherine Saylor, PhD, address concerns on a recent job market study conducted on Twitter that raised ethical questions on the Hastings Bioethics Forum.
Supporting OB-GYNs practicing in states with abortion restrictions just got a little easier, thanks to new recommendations published in JAMA. Kavita S. Arora and Mara Buchbinder are co-authors, with Erika L. Sabbath (Boston College, Harvard University), on a new Viewpoint article in JAMA: “Supporting OB-GYNs in Abortion-Restrictive States—A Playbook for Institutions.” The article offers recommendations … Read more
To raise awareness and assist couples with job searches, UNC-Chapel Hill researchers launched an evidence-based tool showing how research-intensive institutions rank in partner hiring – providing insights on where they may be excelling and where they may be deficient. Jill Fisher, PhD, professor of social medicine at the UNC School of Medicine, co-led the project.
Members of the PRomoting Equity for Pregnant Adolescents in Research (PREPARE) team recently returned from a trip to Botswana and Malawi. This study is led by Principal Investigators (PI) Anne Lyerly, MD, MA, and Kristen Sullivan, PhD, MSW, MBA, of the UNC Center for Bioethics, and includes several UNC Bioethics faculty. While overseas, the PREPARE … Read more
UNC Center for Bioethics core faculty member Jean Cadigan, Ph.D., along with a multidisciplinary team of researchers from across the country, was recently awarded an R01 grant from the National Human Genome Research Institute at NIH entitled, Beyond the Medical: The ELSI of Polygenic Scores for Social Traits.
Annie Lyerly and Kristen Sullivan have been awarded an R01 from the National Institute of Allergy and Infectious Disease (NIAID) to develop empirically informed guidance for conducting ethically responsible HIV/co-infections research with pregnant adolescents. Pregnant adolescents face synergistic challenges in the context of HIV – heightened risk of maternal infection, vertical transmission, and maternal and … Read more
Mara Buchbinder has launched the Study to Examine Physicians’ Pandemic Stress (STEPPS) with funding from the Greenwall Foundation and the National Institute for Occupational Safety and Health. The COVID-19 pandemic has intensified ongoing stress, overwork, and disillusionment among the healthcare workforce. Healthcare professionals responding to the pandemic are experiencing crises of moral integrity and personal … Read more
The Research for Ethical Data Science in Southern Africa (REDSSA) project has the overall aims of producing new knowledge regarding the ethical, legal and social implications (ELSI) of conducting data science research to develop evidence-based, context specific guidance for the conduct and governance of data science initiatives such as DS-I Africa, and to strengthen the … Read more
With funding from the National Institute of Allergy & Infectious Diseases (NIAID), Dr. Jill Fisher is conducting a research study on pediatric clinical trials for food allergies, focusing primarily on peanut allergy. Using ethnographic research methods, the project investigates the on-the-ground ethical challenges that emerge in these clinical trials. In particular, the project explores how … Read more
The increasing pace and international diffusion of developments in human genome editing research have prompted ongoing efforts to develop responsible governance for such research. One point of broad agreement across these efforts is that human genome editing research should prioritize medical applications over attempts to enhance human traits because of the moral concerns the latter … Read more
Comparative Research Ethics and Policy for Phase I Trials Principal Investigators: Jill A. Fisher and Rebecca L. Walker This project addresses the need for a novel evidence-based approach to the protection of Phase I healthy volunteers. Phase I clinical trials test the safety of investigational drugs that eventually may be used in affected patients. These trials … Read more
Despite the high social value of adolescent HIV prevention research in sub-Saharan Africa, investigators are reluctant to involve adolescents in studies with HIV testing and disclosure of results because of ethical concerns about the risks of their participation. This study examines four inter-related ethical issues essential to adolescent HIV research: the effects of disclosure of … Read more
A better understanding of acute HIV infection is essential to public health, impacting both HIV transmission and potential advances in HIV cure clinical research. Acute HIV infection refers to the earliest stages of HIV infection, the short window of time right after a person becomes infected when they are most infectious. Individuals diagnosed and treated … Read more
Project Description Re-Engaging Ethics is a project that is funded by the Greenwall Foundation. The purpose of this project is to create and disseminate recommendations for the review and conduct of community-engaged research, by engaging a diverse set of stakeholders in dialogue about the unique ethical concerns that arise in this emerging scientific approach to … Read more
Francophone African countries are among the most resource-constrained in the world. Citizens in these regions commonly struggle with a wide variety of health problems related to poverty, political conflict and social upheaval. Those involved in local efforts to improve health, in clinical medicine, biomedical research or public health initiatives, often find themselves in difficult situations … Read more
Each year, hundreds of thousands of pregnant women in the US face significant medical illness during their pregnancies, and many more do so worldwide. Diabetes and hypertension complicate 40,000+ pregnancies; psychiatric illness complicates an estimated 500,000; cancer and autoimmune diseases are not uncommon. Yet we have surprisingly little data about how to safely and … Read more
Principal Investigator: Rebecca L. Walker The aim of this project is to develop a virtue ethical approach to biomedical animal research science. A virtue ethical approach to animal research has not yet been developed but the promise of this framework in addressing ethical issues arising within the practice of animal research is significant. In addition, … Read more
Social and Ethical Aspects of Research on Curing HIV A Working Group Co-Principle Investigators: Stuart Rennie Joseph Tucker One of the defining qualities of living with HIV has been that it is incurable, and this tenet has powerfully formed and disrupted individual, organizational, and institutional identities. But recent medical advances have contested this basic fact, … Read more
Principle Investigator: Jill Fisher This project investigates healthy volunteers’ patterns of participation in Phase I clinical trials, with particular attention to the differences among minority groups. The majority of healthy volunteers in clinical trials are serial participants, meaning that they enroll repeatedly in studies, so the research has a longitudinal design to understand volunteers’ patterns … Read more
ARESA Co-Principal Investigators: Keymanthri Moodley (University of Stellenbosch, South Africa) Stuart Rennie (UNC) A collaboration between C:B Core Faculty member Stuart Rennie and colleagues at Stellenbosch University in South Africa has been awarded a grant from the Fogarty International Center of NIH to support research ethics education inSouthern Africa. The Advancing Research Ethics training in Southern … Read more
Co-Principal Investigators Eric Juengst (UNC) Jennifer Fishman (McGill University) Richard Settersten (Oregon State University) “Personalized Genomic Medicine” (PGM) has become a banner which unites a very wide array of scientific, clinical, and commercial initiatives, from medical sequencing and pharmacogenomics research to medical school curricula, public health interventions, nutritional regimes, and direct-to-consumer “recreational” genome scanning. Across … Read more
