Deciding when and how to incorporate patient preferences regarding mode of delivery is challenging for both obstetric providers and policymakers. An analysis of current guidelines in four clinical scenarios (prior cesarean, twin delivery, breech presentation, and maternal request for cesarean) indicates that some guidelines are highly prescriptive whereas others are more flexible, based on physicians’ … Read more

Reasoning well about risk is most challenging when a woman is pregnant, for patient and doctor alike. During pregnancy, we tend to note the risks of medical interventions without adequately noting those of failing to intervene, yet when it’s time to give birth, interventions are seldom questioned, even when they don’t work. Meanwhile, outside the … Read more

With a $3 billion investment by the federal government, the National Children’s Study (NCS) recently began recruitment. The NCS is a golden-and potentially missed-opportunity to study one of the most underrepresented populations in clinical research: pregnant women. As the nation’s largest-ever study of children’s health, the NCS will examine the effects of the environment on … Read more

Though much progress has been made on inclusion of non-pregnant women in research, thoughtful discussion about including pregnant women has lagged behind. We outline resulting knowledge gaps and their costs and then highlight four reasons why ethically we are obliged to confront the challenges of including pregnant women in clinical research. These are: the need … Read more

Over the last several years, as cesarean deliveries have grown increasingly common, there has been a great deal of public and professional interest in the phenomenon of women ‘choosing’ to deliver by cesarean section in the absence of any specific medical indication. The issue has sparked intense conversation, as it raises questions about the nature … Read more

Each year, millions of pregnant women are confronted with serious medical illnesses. Yet the evidence base for treating them is distressingly poor. Due in part to ethical concerns about conducting research with pregnant women, researchers and institutional review boards continue to regard pregnancy as a nearautomatic cause of exclusion, even in studies carrying no additional … Read more