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What Community Review Can and Cannot Do (Commentary)

December 20, 2016
The author praises Sharp and Foster’s differentiation of the forms of “community review,” and agrees that the discussion is far from settled. He argues that rather than attempting to define “community” by various criteria, it might be more helpful to both researchers and research subjects to enable persons to create...

Can Enhancement Be Distinguished From Prevention in Genetic Medicine?

December 20, 2016
In discussions of the ethics of human gene therapy, it has become standard to draw a distinction between the use of human gene transfer techniques to treat health problems and their use to enhance or improve normal human traits. Some dispute the normative force of this distinction by arguing that...

The Human Genome Project and Bioethics

December 20, 2016
In lieu of an abstract, here is a brief excerpt of the content: The fifteen-year “human genome project” at the National Institutes of Health and the Department of Energy officially began on October 1, 1990. With it began a new dimension in federally supported scientific research: concurrent funding for work...

The Clinical Introduction of Genetic Testing for Alzheimer Disease

December 20, 2016
OBJECTIVE: Primary caregivers should be aware of recent progress in the genetics of Alzheimer disease (AD) and of the clinical and ethical considerations raised regarding the introduction of genetic testing for purposes of disease prediction and susceptibility (risk) analysis in asymptomatic individuals and diagnosis in patients who present clinically with...

Cosmetic Surgery for a Fatally Ill Infant

December 20, 2016
The ethical and clinical dimensions of strabismus surgery in a case of an infant with mucolipidosis type II are discussed. Three sets of considerations are relevant to the decision of performing such surgery: professional obligations to protect patients from futile or contraindicated treatment; parental authority to assess the risks and...

Enhancing Cognition in the Intellectually Intact

December 20, 2016
As science learns more about how the brain works, and fails to work, the possibility for developing “cognition enhancers” becomes more plausible. And the demand for drugs that can help us think faster, remember more, and focus more keenly has already been demonstrated by the market success of drugs like...

The NIH “Points to Consider” and the Limits of Human Gene Therapy

December 20, 2016
In this essay, I examine the sources and reach of the NIH “Points to Consider.” These guidelines are based on normative considerations inherited from two sets of science policy deliberations that took place in the United States during the 1970s: the discussion of research with human subjects and the recombinant...

Germ-Line Gene Therapy and the Clinical Ethos of Medical Genetics

December 20, 2016
Although the ability to perform gene therapy in human germ-line cells is still hypothetical, the rate of progress in molecular and cell biology suggests that it will only be a matter of time before reliable clinical techniques will be within reach. Three sets of arguments are commonly advanced against developing...

Casuistry and the Locus of Certainty in Ethics (Review Essay)

December 20, 2016

Carving Nature at Its Joints

December 20, 2016